Protein Details: Glutamate receptor ionotropic; kainate 2

Protein ID

ICDB_Pro_0516

Protein Name

Glutamate receptor ionotropic; kainate 2

Gene Name

Grik2; Glur6

Organism

Mus musculus (Mouse)

Length

908 amino acids

AlphaFoldDB

AF-P39087-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel; gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change; leading to the opening of the cation channel; and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state; characterized by the presence of bound agonist. Modulates cell surface expression of NETO2. In association with GRIK3; involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses. Independent of its ionotropic glutamate receptor activity; acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons. [Isoform GluR6-2]: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel; gated by L-glutamate and the glutamatergic agonist kainic acid.

Sequence

MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPSSGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 516; /ligand="L-glutamate"; BINDING 518; /ligand="L-glutamate"; BINDING 523; /ligand="L-glutamate"; BINDING 689; /ligand="L-glutamate"; BINDING 690; /ligand="L-glutamate"; BINDING 738; /ligand="L-glutamate"

Disease

Location

Expressed in the hippocampal mossy fiber synapses (at protein level) (PubMed:12954862). Most abundant in the cerebellum and the hypothalamus. Expressed in a proportion of dorsal root ganglion (DRG) neurons (13. Expressed in a proportion of dorsal root ganglion (DRG) neurons (13. Expressed in a proportion of dorsal root ganglion (DRG) neurons (13.6%); predominantly small diameter DRG neurons (75%) with the remainder expressed in medium diameter DRG neurons (PubMed:31474366)

DOI ID

10.1097/00001756-199309150-00014; 10.1016/0169-328x(92)90023-5; 10.1073/pnas.93.5.1875; 10.1016/0896-6273(93)90336-p; 10.1371/journal.pbio.1000112; 10.1523/jneurosci.23-22-08013.2003; 10.1074/mcp.t500041-mcp200; 10.1073/pnas.0608891104; 10.1523/jneurosci.2724-09.2009; 10.1016/j.neuron.2008.12.014; 10.1016/j.cell.2010.12.001; 10.1016/j.cell.2019.07.034

RefSeq

XP_017169293.1